Bone Abstracts

Background: Isotretinoin has demonstrated efficacy in a wide range of disorders. The beneficial effects of the drug, however, are limited by its adverse impact on the bone. Children exposed to high doses are at risk for premature epiphyseal closure, while adults on long-term therapy have an increased tendency to develop hyperostosis and other changes of the bone. Presenting feature and Clinical management A 9-month-old infant presented with vomiting and distended abdomen due t...

Background: Acroosteolysis is a term used to describe bone resorption of the hands and toes. Typically involving distal phalanges, its causes may be hereditary, inflammatory, traumatic, toxin-mediated or idiopathic non-familial.Presenting problem: An 11-year old Chinese girl presented to the dermatology clinic with nail resorption of the left index finger for 1 year. She was previously well with no history of connective tissue disorders and no history of...